Drug General Information
Drug ID	D0VP6M
Former ID	DNC003700
Drug Name	1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525916]
Structure		Download 2D MOL 3D MOL
Formula	C14H15NO3
Canonical SMILES	CC(C)(C)C(=O)CN1C2=CC=CC=C2C(=O)C1=O
InChI	1S/C14H15NO3/c1-14(2,3)11(16)8-15-10-7-5-4-6-9(10)12(17)13(15)18/h4-7H,8H2,1-3H3
InChIKey	GGQBSDZGSYIVQW-UHFFFAOYSA-N
PubChem Compound ID	3659236
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[525916]
	Plasminogen	Target Info	Inhibitor	[525916]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosushsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Staphylococcus aureus infection
	Influenza A
PANTHER Pathway	Blood coagulation
	Plasminogen activating cascade
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
	p75(NTR)-mediated signaling
	amb2 Integrin signaling
	Syndecan-4-mediated signaling events
PathWhiz Pathway	Coagulation
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix MetalloproteinasesR-HSA-114608:Platelet degranulation
	Activation of Matrix Metalloproteinases
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Dissolution of Fibrin Clot
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagenWP558:Complement and Coagulation Cascades
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Activation of Matrix Metalloproteinases
	Blood Clotting Cascade
	Dissolution of Fibrin Clot
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 525916	Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.Parallel synthesis of isatin-based serine protease inhibitors.
Ref 525916	Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.Parallel synthesis of isatin-based serine protease inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.