| Drug General Information |
| Drug ID |
D0VP6M
|
| Former ID |
DNC003700
|
| Drug Name |
1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H15NO3
|
| Canonical SMILES |
CC(C)(C)C(=O)CN1C2=CC=CC=C2C(=O)C1=O
|
| InChI |
1S/C14H15NO3/c1-14(2,3)11(16)8-15-10-7-5-4-6-9(10)12(17)13(15)18/h4-7H,8H2,1-3H3
|
| InChIKey |
GGQBSDZGSYIVQW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Leukocyte elastase |
Target Info |
Inhibitor |
[1]
|
|---|
| Plasminogen |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Transcriptional misregulation in cancer
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Systemic lupus erythematosushsa04080:Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Staphylococcus aureus infection
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Influenza A
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PANTHER Pathway
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Blood coagulation
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Plasminogen activating cascade
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Pathway Interaction Database
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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C-MYB transcription factor networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
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p75(NTR)-mediated signaling
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amb2 Integrin signaling
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Syndecan-4-mediated signaling events
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PathWhiz Pathway
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Coagulation
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Reactome
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Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix MetalloproteinasesR-HSA-114608:Platelet degranulation
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Activation of Matrix Metalloproteinases
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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Dissolution of Fibrin Clot
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WikiPathways
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Human Complement System
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Degradation of collagenWP558:Complement and Coagulation Cascades
|
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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Activation of Matrix Metalloproteinases
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Blood Clotting Cascade
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Dissolution of Fibrin Clot
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.Parallel synthesis of isatin-based serine protease inhibitors. |
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