Drug General Information
Drug ID
D0V8QT
Former ID
DAP000787
Drug Name
Chlorambucil
Synonyms
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
Drug Type
Small molecular drug
Indication Chronic lymphocytic leukaemia [ICD10:C91] Approved [538433], [542151]
Therapeutic Class
Anticancer Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C14H19Cl2NO2
InChI
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N
CAS Number
CAS 305-03-3
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:28830
SuperDrug ATC ID
L01AA02
SuperDrug CAS ID
cas=000305033
Target and Pathway
Target(s) DNA Target Info Intercalator [537444]
References
Ref 538433FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010669.
Ref 542151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7143).
Ref 537444Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23. Epub 2009 Jun 9.

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