Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V7XF
|
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| Former ID |
DNAP001469
|
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| Drug Name |
Dopexamine
|
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| Synonyms |
Dopacard (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | Cardiac failure [ICD10:I50] | Approved | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H32N2O2
|
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| Canonical SMILES |
C1=CC=C(C=C1)CCNCCCCCCNCCC2=CC(=C(C=C2)O)O
|
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| InChI |
1S/C22H32N2O2/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2
|
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| InChIKey |
RYBJORHCUPVNMB-UHFFFAOYSA-N
|
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| CAS Number |
CAS 86197-47-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7979123, 8184158, 12012934, 14925749, 17397975, 43113454, 50065324, 50919023, 57313761, 85211552, 103278029, 104307717, 124896575, 129198273, 135014092, 137001293, 140438698, 142950050, 144206582, 163693528, 163852961, 164814733, 170466408, 172886729, 179151325, 198975207, 223554814, 225384107, 226493570, 252348780
|
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| SuperDrug ATC ID |
C01CA14
|
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| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
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