Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V7HD
|
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| Former ID |
DIB007860
|
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| Drug Name |
BN-50726
|
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| Drug Type |
Small molecular drug
|
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| Indication | Nerve injury [ICD10:T14.4] | Terminated | [1] | ||
| Company |
Ipsen
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C34H48ClN5O2S2
|
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| Canonical SMILES |
c12c(C(=NCc3n1c(nn3)C)c1c(Cl)cccc1)c1c(s2)CN(S(=O)(=O)C<br />CCCCCCCCCCCCCCC)CC1
|
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| CAS Number |
CAS 127279-06-5
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001821) | ||||
| REF 2 | Effects of the PAF antagonists BN50726 and BN50739 on arrhythmogenesis and extent of necrosis during myocardial ischaemia/reperfusion in rabbits. Br J Pharmacol. 1992 Nov;107(3):705-9. | ||||
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