Drug General Information
Drug ID	D0V7GC
Former ID	DIB008730
Drug Name	Rolafagrel
Synonyms	FCE-22178
Drug Type	Small molecular drug
Indication	Nephritis [ICD10:N00-N19, N25-N29]		Discontinued in Phase 2	[544896]
Company	Pharmacia & Upjohn AB
Structure		Download 2D MOL 3D MOL
Formula	C14H12N2O2
Canonical SMILES	C1(=Cc2cc(C(=O)O)ccc2CC1)n1cncc1
CAS Number	CAS 89781-55-5
PubChem Compound ID	56009
Target and Pathway
Target(s)	Thromboxane-A synthase	Target Info	Inhibitor	[529293]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
References
Ref 544896	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001438)
Ref 529293	Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:707-10.

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