Drug Information

Drug General Information
Drug ID
D0V7FG
Former ID
DIB013017
Drug Name
SPH-1285
Synonyms
Galantamine derivatives, Sanochemia; SPH-1285; SPH-1286; SPH-1359
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Preclinical [547351]
Company
Sanochemia Pharmazeutika AG
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@@]123c4c(O[C@@H]1C[C@H](C=C2)O)c(ccc4CN(CC3)CCCN1CCC<br />CC1)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
CAS Number
CAS 273930-29-3
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [525994]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 547351Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015422)
Ref 525994Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease. Biol Psychiatry. 2001 Feb 1;49(3):289-99.

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