Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V6VQ
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| Former ID |
DIB004056
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| Drug Name |
PF-956980
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| Synonyms |
Janus kinase 3 inhibitors (inflammation); PF-956980; JAK3 inhibitors (inflammation), Pfizer; Janus kinase 3 inhibitors (inflammation), Pfizer
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| Indication | Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] | Investigative | [1] | ||
| Company |
Pfizer Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C1CCCN1C(=O)N1C[C@H](N(c2ncnc3c2cc[nH]3)C)[C@@H](CC1)C
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| Target and Pathway | |||||
| Target(s) | Tyrosine-protein kinase JAK3 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Chemokine signaling pathway | ||||
| PI3K-Akt signaling pathway | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Jak-STAT signaling pathway | |||||
| Measles | |||||
| HTLV-I infection | |||||
| Epstein-Barr virus infection | |||||
| Viral carcinogenesis | |||||
| Primary immunodeficiency | |||||
| PANTHER Pathway | Interleukin signaling pathway | ||||
| JAK/STAT signaling pathway | |||||
| PDGF signaling pathway | |||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| CD40/CD40L signaling | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| IL2-mediated signaling events | |||||
| IL2 signaling events mediated by PI3K | |||||
| IL2 signaling events mediated by STAT5 | |||||
| Reactome | GPVI-mediated activation cascade | ||||
| Interleukin-7 signaling | |||||
| G beta:gamma signalling through PI3Kgamma | |||||
| Interleukin-2 signaling | |||||
| RAF/MAP kinase cascade | |||||
| Interleukin receptor SHC signaling | |||||
| WikiPathways | IL-2 Signaling Pathway | ||||
| IL-4 Signaling Pathway | |||||
| Interleukin-2 signaling | |||||
| Interleukin-7 signaling | |||||
| Oncostatin M Signaling Pathway | |||||
| IL-9 Signaling Pathway | |||||
| IL-7 Signaling Pathway | |||||
| Interleukin-3, 5 and GM-CSF signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). | ||||
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