Drug Information

Drug General Information
Drug ID
D0V4ZA
Former ID
DNC000325
Drug Name
Bisphosphonates
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Investigative [535202]
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535202]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 535202Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. Epub 2001 Jul 2.
Ref 535202Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. Epub 2001 Jul 2.

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