Drug Information

Drug General Information
Drug ID
D0V4NW
Former ID
DNC009292
Drug Name
N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529734]
Structure
Download
2D MOL

3D MOL
Formula
C23H32N2O
Canonical SMILES
CCCN(CCC)CCCCNC(=O)C1=CC=C(C=C1)C2=CC=CC=C2
InChI
1S/C23H32N2O/c1-3-17-25(18-4-2)19-9-8-16-24-23(26)22-14-12-21(13-15-22)20-10-6-5-7-11-20/h5-7,10-15H,3-4,8-9,16-19H2,1-2H3,(H,24,26)
InChIKey
HXCWGVSINJYYSW-UHFFFAOYSA-N
PubChem Compound ID
25139332
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [529734]
Dopamine D1 receptor Target Info Inhibitor [529734]
D(2) dopamine receptor Target Info Inhibitor [529734]
D(4) dopamine receptor Target Info Inhibitor [529734]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
GPCRs, Other
References
Ref 529734J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Ref 529734J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.