Drug General Information
Drug ID	D0V4KL
Former ID	DIB014025
Drug Name	VAR-10200
Synonyms	HLA-20
Drug Type	Small molecular drug
Indication	Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32]		Investigative	[543639]
Company	Varinel Inc
Structure		Download 2D MOL 3D MOL
Formula	C17H19N3O
Canonical SMILES	c1cc(c2c(c1)c(ccn2)CN1CCN(CC1)CC#C)O
PubChem Compound ID	6918819
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] B	Target Info	Modulator	[543639]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
WikiPathways	Tryptophan metabolism
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
References
Ref 543639	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).
Ref 543639	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).

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