| Drug General Information |
| Drug ID |
D0V4GT
|
| Former ID |
DIB001203
|
| Drug Name |
CMI-206
|
| Synonyms |
IDDB8444
|
| Indication |
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]
|
Terminated |
[1]
|
|---|
| Company |
CytoMed Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
C(=O)(Nc1c(c(cc([C@H]2O[C@H](c3cc(c(c(c3)OC)OC)OC)CC2)c<br />1)OC)OCCC)N(O)CCCC
|
| Target and Pathway |
| Target(s) |
Arachidonate 5-lipoxygenase |
Target Info |
Modulator |
|
|---|
| Platelet-activating factor receptor |
Target Info |
Modulator |
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
|
Leukotriene biosynthesis
|
|
Lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
Aspirin triggered resolvin E biosynthesis
|
|
KEGG Pathway
|
Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
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Toxoplasmosishsa04020:Calcium signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Staphylococcus aureus infection
|
|
NetPath Pathway
|
IL4 Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
Leptin Signaling Pathway
|
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PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
Reactome
|
Class A/1 (Rhodopsin-like receptors)
|
|
G alpha (q) signalling events
|
|
Interferon gamma signaling
|
|
WikiPathways
|
Vitamin D Receptor Pathway
|
|
Arachidonic acid metabolism
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP455:GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Small Ligand GPCRs
|
|
Interferon gamma signaling
|
|
GPCR ligand binding
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|
GPCR downstream signaling
|
| References |
| REF 1 | Cmi206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor. Bioorganic & Medicinal Chemistry Letters. 03/1995; 5(6):643-648. |
|---|
