Drug General Information
Drug ID	D0V4GI
Former ID	DNC011501
Drug Name	CGS-9896
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[1]
Structure		Download 2D MOL 3D MOL
Formula	C16H10ClN3O
Canonical SMILES	C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI	1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H
InChIKey	QCBUAKLOWCOUCR-UHFFFAOYSA-N
PubChem Compound ID	108030
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[2]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[2]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[2]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[2]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transport
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000585)
REF 2	J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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