Drug General Information
Drug ID
D0V3WQ
Former ID
DIB010349
Drug Name
Sch-207758
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [547062]
Company
Schering-Plough Corp
Structure
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2D MOL

3D MOL

Canonical SMILES
c12c3c([nH]cc3C)c(cc2CCc2c([C@@H]1C1CCN(C(=O)Cc3cc[n+](<br />[O-])cc3)CC1)nccc2)Cl
CAS Number
CAS 410074-09-8
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [526408]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 547062Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012642)
Ref 526408Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase. J Med Chem. 2002 Aug 29;45(18):3854-64.

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