| Drug General Information |
| Drug ID |
D0V3SO
|
| Former ID |
DNC002853
|
| Drug Name |
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H17N3O2S
|
| Canonical SMILES |
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
|
| InChI |
1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
|
| InChIKey |
NGOGFTYYXHNFQH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
645246, 830160, 841200, 7411211, 7888736, 8152246, 11113364, 11121731, 11122211, 11362865, 11365427, 11367989, 11370941, 11370942, 11373590, 11376151, 14849184, 26751605, 26751606, 29222678, 46392968, 46394056, 46394198, 46514392, 47810568, 47959546, 48034909, 48110269, 48184808, 49961274, 50100814, 50871527, 53790340, 57321867, 81062559, 85787246, 85787262, 91614085, 92251456, 92308789, 92310082, 92708292, 93577882, 96024636, 99300994, 99302514, 99444633, 103064513, 103083244, 103210437
|
| Target and Pathway |
| Target(s) |
Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
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TGF-beta signaling pathway
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Axon guidance
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Focal adhesion
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Platelet activation
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Leukocyte transendothelial migration
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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PANTHER Pathway
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Cytoskeletal regulation by Rho GTPase
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Signaling events mediated by PRL
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RhoA signaling pathway
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Noncanonical Wnt signaling pathway
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EPHB forward signaling
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Thromboxane A2 receptor signaling
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PAR4-mediated thrombin signaling events
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amb2 Integrin signaling
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Integrins in angiogenesis
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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N-cadherin signaling events
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Reactome
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Apoptotic cleavage of cellular proteins
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
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G alpha (12/13) signalling events
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Sema4D induced cell migration and growth-cone collapse
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VEGFA-VEGFR2 Pathway
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RHO GTPases Activate ROCKs
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WikiPathways
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G13 Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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Focal Adhesion
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JAK/STAT
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AGE/RAGE pathway
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Pathogenic Escherichia coli infection
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Regulation of Microtubule Cytoskeleton
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Leptin signaling pathway
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Semaphorin interactions
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Integrin-mediated Cell Adhesion
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GPCR downstream signaling
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Apoptotic execution phase
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
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