Drug Information
Drug General Information | |||||
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Drug ID |
D0V3NT
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Former ID |
DNC005392
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Drug Name |
TOLOXATONE
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [528273] | ||
Structure |
Download2D MOL |
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Formula |
C11H13NO3
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Canonical SMILES |
CC1=CC(=CC=C1)N2CC(OC2=O)CO
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InChI |
1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
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InChIKey |
MXUNKHLAEDCYJL-UHFFFAOYSA-N
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CAS Number |
CAS 29218-27-7
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PubChem Compound ID | |||||
SuperDrug ATC ID |
N06AG03
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Target and Pathway | |||||
Target(s) | Amine oxidase [flavin-containing] A | Target Info | Inhibitor | [528273] | |
Amine oxidase [flavin-containing] B | Target Info | Inhibitor | [526287] | ||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Dopamine degradation | |||||
Putrescine degradation III | |||||
Noradrenaline and adrenaline degradation | |||||
Serotonin degradation | |||||
Superpathway of melatonin degradation | |||||
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization | |||||
Tryptophan degradation via tryptamine | |||||
KEGG Pathway | Glycine, serine and threonine metabolism | ||||
Arginine and proline metabolism | |||||
Histidine metabolism | |||||
Tyrosine metabolism | |||||
Phenylalanine metabolism | |||||
Tryptophan metabolism | |||||
Drug metabolism - cytochrome P450 | |||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Dopaminergic synapse | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Alcoholismhsa00260:Glycine, serine and threonine metabolism | |||||
Alcoholism | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
References | |||||
Ref 526287 | J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. | ||||
Ref 528273 | J Nat Prod. 2006 Jun;69(6):945-9.Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and computational study. |
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