Drug General Information
Drug ID	D0V2YJ
Former ID	DIB002509
Drug Name	MK-0731
Synonyms	C-4251; MK-731
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[521631]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Formula	C25H28F3N3O2
Canonical SMILES	c1(C2=C[C@](c3ccccc3)(CO)N(C(=O)N([C@H]3CCN(C[C@H]3F)C)<br />C)C2)c(ccc(c1)F)F
PubChem Compound ID	11655511
Target and Pathway
Target(s)	Kinesin-like protein KIF11	Target Info	Inhibitor	[531974]
Reactome	MHC class II antigen presentation
	Kinesins
WikiPathways	MHC class II antigen presentation
	Kinesins
References
Ref 521631	ClinicalTrials.gov (NCT00104364) A Study of MK0731 in Patients With Advanced Solid Tumors (0731-002)(COMPLETED). U.S. National Institutes of Health.
Ref 531974	Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.

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