Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V2YJ
|
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| Former ID |
DIB002509
|
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| Drug Name |
MK-0731
|
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| Synonyms |
C-4251; MK-731
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 1 | [1] | ||
| Company |
Merck & Co Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H28F3N3O2
|
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| Canonical SMILES |
c1(C2=C[C@](c3ccccc3)(CO)N(C(=O)N([C@H]3CCN(C[C@H]3F)C)<br />C)C2)c(ccc(c1)F)F
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Kinesin-like protein KIF11 | Target Info | Inhibitor | [2] | |
| Reactome | MHC class II antigen presentation | ||||
| Kinesins | |||||
| WikiPathways | MHC class II antigen presentation | ||||
| Kinesins | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00104364) A Study of MK0731 in Patients With Advanced Solid Tumors (0731-002)(COMPLETED). U.S. National Institutes of Health. | ||||
| REF 2 | Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. | ||||
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