Drug General Information
Drug ID	D0V2RK
Former ID	DIB008418
Drug Name	NKP-46
Synonyms	FFC-11; KP-46
Drug Type	Antibody
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Preclinical	[546342]
Company	University of Vienna
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(c(ccc1)[O-])nccc2.[GaH3+3].c12c(c(ccc1)[O-])nccc2.<br />c12c(c(ccc1)[O-])nccc2
CAS Number	CAS 14642-34-3
Target and Pathway
Target(s)	Ribonucleoside-diphosphatereductase subunit M2	Target Info		[549988]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Guanosine nucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Adenosine deoxyribonucleotides de novo biosynthesis
	Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Glutathione metabolism
	Metabolic pathways
	p53 signaling pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	p53 pathway
	De novo purine biosynthesis
	De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Purine Metabolism
	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Retinoblastoma (RB) in Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 546342	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007583)
Ref 549988	Phase I and pharmacokinetic study of the oral tris-(8-quinolinolato)gallium(III) complex (FFC11, KP46) in patients with solid tumors - a study of the CESAR Central European Society for Anticancer Drug Research - EWIV. J Clin Oncol (Meeting Abstracts) June 2005 vol. 23 no. 16_suppl 3205.

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