Drug General Information
Drug ID	D0V0NJ
Former ID	DNC012507
Drug Name	2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534195]
Structure		Download 2D MOL 3D MOL
Formula	C9H12N2
Canonical SMILES	C1CNC2=CC=CC=C2CN1
InChI	1S/C9H12N2/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-4,10-11H,5-7H2
InChIKey	MLXBHOCKBUILHN-UHFFFAOYSA-N
PubChem Compound ID	2771762
Target and Pathway
Target(s)	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534195]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534195]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534195]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
References
Ref 534195	J Med Chem. 1996 Aug 30;39(18):3539-46.Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.
Ref 534195	J Med Chem. 1996 Aug 30;39(18):3539-46.Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.

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