| Drug General Information |
| Drug ID |
D0V0KA
|
| Former ID |
DIB019356
|
| Drug Name |
compound 22
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C20H18ClN3O2
|
| InChI |
InChI=1S/C20H18ClN3O2/c21-16-11-15-13(8-9-22-19(15)25)10-17(16)24-20(26)18(23-14-6-7-14)12-4-2-1-3-5-12/h1-5,8-11,14,18,23H,6-7H2,(H,22,25)(H,24,26)
|
| InChIKey |
SKYALJGMRAGHEN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| NIMA-related kinase 7 |
Target Info |
Inhibitor |
[1]
|
| Rho associated protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
| NIMA-related kinase 6 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
|
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TGF-beta signaling pathway
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Axon guidance
|
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Focal adhesion
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Platelet activation
|
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Leukocyte transendothelial migration
|
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
|
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Pathways in cancer
|
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Proteoglycans in cancer
|
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MicroRNAs in cancerhsa04022:cGMP-PKG signaling pathway
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Wnt signaling pathway
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PANTHER Pathway
|
Cytoskeletal regulation by Rho GTPase
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
|
|
Pathway Interaction Database
|
Signaling events mediated by PRL
|
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RhoA signaling pathway
|
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Noncanonical Wnt signaling pathway
|
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EPHB forward signaling
|
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Thromboxane A2 receptor signaling
|
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PAR4-mediated thrombin signaling events
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amb2 Integrin signaling
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Integrins in angiogenesis
|
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
|
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N-cadherin signaling eventsrhoa_pathway:RhoA signaling pathway
|
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Plasma membrane estrogen receptor signaling
|
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Osteopontin-mediated events
|
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PLK1 signaling events
|
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Signaling events mediated by focal adhesion kinase
|
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Reactome
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Apoptotic cleavage of cellular proteins
|
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EPHB-mediated forward signaling
|
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EPHA-mediated growth cone collapse
|
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G alpha (12/13) signalling events
|
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Sema4D induced cell migration and growth-cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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RHO GTPases Activate ROCKsR-HSA-3928662:EPHB-mediated forward signaling
|
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RHO GTPases Activate ROCKs
|
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WikiPathways
|
G13 Signaling Pathway
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Regulation of Actin Cytoskeleton
|
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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Focal Adhesion
|
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JAK/STAT
|
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AGE/RAGE pathway
|
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Pathogenic Escherichia coli infection
|
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Regulation of Microtubule Cytoskeleton
|
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Leptin signaling pathway
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Semaphorin interactions
|
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Integrin-mediated Cell Adhesion
|
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GPCR downstream signaling
|
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Apoptotic execution phase
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
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Spinal Cord Injury
|
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Androgen receptor signaling pathway
|
| References |
| REF 1 | Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3235-9. |
|---|
