Drug Information
Drug General Information | |||||
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Drug ID |
D0UZ9U
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Former ID |
DNC003573
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Drug Name |
PREMETREXED
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Phase 2 | [521700] | ||
Structure |
Download2D MOL |
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Formula |
C20H21N5O6
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Canonical SMILES |
C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)<br />C(=O)O
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InChI |
1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)
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InChIKey |
WBXPDJSOTKVWSJ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Dihydrofolate reductase | Target Info | Inhibitor | [535186] | |
Thymidylate synthase | Target Info | Inhibitor | [528001] | ||
BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Superpathway of pyrimidine deoxyribonucleoside salvage | |||||
DTMP de novo biosynthesis (mitochondrial) | |||||
Pyrimidine deoxyribonucleosides salvage | |||||
Pathway Interaction Database | E2F transcription factor network | ||||
PathWhiz Pathway | Folate Metabolism | ||||
Pterine BiosynthesisPW000160:Pyrimidine Metabolism | |||||
WikiPathways | Trans-sulfuration and one carbon metabolism | ||||
Retinoblastoma (RB) in Cancer | |||||
One Carbon Metabolism | |||||
Integrated Pancreatic Cancer Pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
Metabolism of nucleotides | |||||
Fluoropyrimidine Activity | |||||
References | |||||
Ref 528001 | J Med Chem. 2006 Feb 9;49(3):1055-65.Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). | ||||
Ref 535186 | Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. J Med Chem. 2001 Jun 7;44(12):1993-2003. |
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