Drug Information

Drug General Information
Drug ID
D0UL7R
Former ID
DIB020952
Drug Name
SKA-31
Synonyms
2-aminonaphthiazole; 2-amino-beta-naphthothiazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539479]
Structure
Download
2D MOL
Formula
C11H8N2S
InChI
InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChIKey
FECQXVPRUCCUIL-UHFFFAOYSA-N
PubChem Compound ID
94880
PubChem Substance ID
72267, 3156347, 3896230, 5088516, 6431769, 10226800, 24349684, 44425425, 47194328, 47548093, 48368384, 51887739, 58033031, 72275214, 85163794, 85183726, 88877473, 103840202, 104413886, 104660167, 117521039, 117529682, 117529683, 117529692, 118184128, 125141925, 125410769, 127833635, 130917154, 131290352, 131351698, 135050694, 135651046, 137014460, 143407326, 144023868, 162099064, 162159716, 163565862, 164796410, 164850569, 164868386, 170250164, 170558646, 176278822, 180095770, 184565453, 223258928, 224052761, 225226466
Target and Pathway
Target(s) KCa3.1 Target Info Activator [529778]
References
Ref 539479(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2335).
Ref 529778Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95.

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