Drug Information

Drug General Information
Drug ID
D0U9JL
Former ID
DIB016997
Drug Name
LY-223982
Synonyms
CGS-23131; LY-223980; LY-255253; SKF-107324
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [540360], [545163]
Company
Eli Lilly & Co
Structure
Download
2D MOL

3D MOL
Formula
C30H30O7
InChI
InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
InChIKey
SYZSSLLFRVDRHL-QPJJXVBHSA-N
CAS Number
CAS 117423-74-2
PubChem Compound ID
6444688
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Modulator [526763]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
References
Ref 540360(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3415).
Ref 545163Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002326)
Ref 526763Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.

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