Drug Information
Drug General Information | |||||
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Drug ID |
D0U9IQ
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Former ID |
DCL001077
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Drug Name |
PF-477736
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Drug Type |
Small molecular drug
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Company |
Pfizer
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Structure |
Download2D MOL |
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Formula |
C22H25N7O2
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InChI |
InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,24H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1
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InChIKey |
YFNWWNRZJGMDBR-LJQANCHMSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
26738683, 134339473, 135267502, 135653612, 136920310, 137275976, 142910601, 152258067, 152344328, 160646905, 162009842, 162011615, 162205240, 162249186, 172650635, 174007106, 177749453, 189614649, 198964618, 203090938, 223705255, 238593669, 241376902, 243967249, 251963197, 252157928, 252160096, 252450359, 252543444
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Target and Pathway | |||||
Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [537564] | |
Pathway Interaction Database | Fanconi anemia pathway | ||||
p73 transcription factor network | |||||
ATR signaling pathway | |||||
Circadian rhythm pathway | |||||
p53 pathway | |||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
References | |||||
Ref 542941 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8043). | ||||
Ref 548144 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022394) |
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