Drug Information

Drug General Information
Drug ID
D0U8VY
Former ID
DIB018914
Drug Name
quinazoline deriv. 1
Synonyms
quinazoline deriv. 1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541216]
Structure
Download
2D MOL

3D MOL
Formula
C23H20N4O3
InChI
InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
InChIKey
IMYVCWQAHSYYOO-UHFFFAOYSA-N
PubChem Compound ID
6610278
PubChem Substance ID
11120228, 11120716, 11121204, 11147311, 14720361, 14854727, 17187737, 26758270, 43230009, 46512872, 53800968, 78924909, 99302623, 103482401, 114644685, 127325718, 128191197, 134345595, 163123733, 163688561, 175607391, 178102553, 180371690, 204380081, 208265175, 227314159
Target and Pathway
Target(s) mRNA of Aurora B Target Info Inhibitor [529213]
Aurora protein kinase Target Info Inhibitor [529213]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
WikiPathways Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 541216(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5930).
Ref 529213Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.