Drug General Information
Drug ID	D0U8FC
Former ID	DNC010784
Drug Name	N-(2-aminophenyl)benzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530853]
Structure		Download 2D MOL 3D MOL
Formula	C13H12N2O
Canonical SMILES	C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N
InChI	1S/C13H12N2O/c14-11-8-4-5-9-12(11)15-13(16)10-6-2-1-3-7-10/h1-9H,14H2,(H,15,16)
InChIKey	RFDVMOUXHKTCDO-UHFFFAOYSA-N
PubChem Compound ID	759408
Target and Pathway
Target(s)	Histone deacetylase 2	Target Info	Inhibitor	[530853]
KEGG Pathway	Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Alcoholism
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	Chronic myeloid leukemia
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Wnt signaling pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Direct p53 effectors
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcription
Reactome	p75NTR negatively regulates cell cycle via SC1
	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Notch Signaling Pathway
	Notch Signaling Pathway
	Neural Crest Differentiation
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
References
Ref 530853	Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. Epub 2010 Mar 30.Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.
Ref 530853	Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. Epub 2010 Mar 30.Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

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