Drug Information

Drug General Information
Drug ID
D0U7XP
Former ID
DNC014828
Drug Name
Alpha,beta-methylene-dGTP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529712]
Structure
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2D MOL

3D MOL
Formula
C11H18N5O12P3
Canonical SMILES
C1C(C(OC1N2C=NC3=C2NC(=NC3=O)N)COP(=O)(CP(=O)(O)OP(=O)(<br />O)O)O)O
InChI
1S/C11H18N5O12P3/c12-11-14-9-8(10(18)15-11)13-3-16(9)7-1-5(17)6(27-7)2-26-29(19,20)4-30(21,22)28-31(23,24)25/h3,5-7,17H,1-2,4H2,(H,19,20)(H,21,22)(H2,23,24,25)(H3,12,14,15,18)/t5-,6+,7+/m0/s1
InChIKey
JTBKCZGNQPBEJY-RRKCRQDMSA-N
PubChem Compound ID
25129494
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [529712]
References
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

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