Drug Information

Drug General Information
Drug ID
D0U7IL
Former ID
DNCL002882
Drug Name
LX-4211
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [524151], [543064]
Company
Lexicon Pharmaceuticals
Structure
Download
2D MOL
Formula
C21H25ClO5S
InChI
InChI=1S/C21H25ClO5S/c1-3-26-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(27-20)28-2/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1
InChIKey
QKDRXGFQVGOQKS-CRSSMBPESA-N
PubChem Compound ID
24831714
PubChem Substance ID
49853536, 57140200, 137346808, 163620939, 163643067, 163686261, 163763206, 174510188, 185978790, 198963852, 223389144, 223404368, 223471389, 227288514, 242060148, 242939387, 249733296, 252153681, 252166524, 252215725, 252479434, 252811352
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Modulator [531953]
SLGT2 Target Info Modulator [531953]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP2884:NRF2 pathway
Nuclear Receptors Meta-Pathway
References
Ref 524151ClinicalTrials.gov (NCT01742208) Safety and Efficacy of LX4211 in Patients With Inadequately Controlled Type 1 Diabetes Mellitus. U.S. National Institutes of Health.
Ref 543064(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8312).
Ref 531953LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92(2):158-69.

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