Drug Information

Drug General Information
Drug ID
D0U6ML
Former ID
DNC000440
Drug Name
CKD602
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [521961]
Structure
Download
2D MOL

3D MOL
Formula
C25H28ClN3O4
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC<br />(C)C)O.Cl
InChI
1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1
InChIKey
SJKBXKKZBKCHET-UQIIZPHYSA-N
CAS Number
CAS 256411-32-2
PubChem Compound ID
6918340
PubChem Substance ID
12015068, 14907463, 14907464, 17194827, 17397378, 43529718, 50913634, 57371893, 126681060, 135252488, 160687459, 162255311, 198969553, 223664191, 252166952
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [538150]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 521961ClinicalTrials.gov (NCT00430144) Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix. U.S. National Institutes of Health.
Ref 538150Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor. Arch Pharm Res. 1998 Oct;21(5):581-90.

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