Drug General Information
Drug ID	D0U6IL
Former ID	DNC012638
Drug Name	1-Aminomethyl-isochroman-5,6-diol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530404]
Structure		Download 2D MOL 3D MOL
Formula	C10H13NO3
Canonical SMILES	C1COC(C2=C1C(=C(C=C2)O)O)CN
InChI	1S/C10H13NO3/c11-5-9-6-1-2-8(12)10(13)7(6)3-4-14-9/h1-2,9,12-13H,3-5,11H2
InChIKey	JBSRTZUQAXYSQB-UHFFFAOYSA-N
PubChem Compound ID	13864381
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[530404]
	Dopamine D1 receptor	Target Info	Inhibitor	[530404]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04020:Calcium signaling pathway
	Amphetamine addiction
	Morphine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (s) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
References
Ref 530404	J Med Chem. 1990 Nov;33(11):2948-50.(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
Ref 530404	J Med Chem. 1990 Nov;33(11):2948-50.(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.

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