Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U6BQ
|
||||
| Former ID |
DIB001919
|
||||
| Drug Name |
Anti-VEGFR2 CD8 cell therapy
|
||||
| Synonyms |
Autologous T-lymphocyte cell therapy; Anti-VEGFR2 CD8 cell therapy (cancer)
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 1/2 | [523207] | ||
| Company |
Pervasis Therapeutics
|
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | Modulator | [523207], [532072] | |
| T-cell surface glycoprotein CD8 | Target Info | Modulator | [523207], [532072] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04514:Cell adhesion molecules (CAMs) | |||||
| Antigen processing and presentation | |||||
| Hematopoietic cell lineage | |||||
| T cell receptor signaling pathway | |||||
| Primary immunodeficiency | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
| Ref 523207 | ClinicalTrials.gov (NCT01218867) CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic Cancer. U.S. National Institutes of Health. | ||||
| Ref 532072 | Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6. | ||||
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