Drug Information

Drug General Information
Drug ID
D0U5KM
Former ID
DNC003720
Drug Name
Ac-His-DPhe-Arg-Trp-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534420]
Structure
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2D MOL

3D MOL
Formula
C34H43N11O5
Canonical SMILES
CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C<br />(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
InChI
1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1
InChIKey
DFCJPPDAOZROBS-DZUOILHNSA-N
PubChem Compound ID
10484741
Target and Pathway
Target(s) Melanocyte stimulating hormone receptor Target Info Inhibitor [534420]
Melanocortin-4 receptor Target Info Inhibitor [534420]
KEGG Pathway Neuroactive ligand-receptor interaction
Melanogenesishsa04080:Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 534420J Med Chem. 1997 Jul 4;40(14):2133-9.Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Ref 534420J Med Chem. 1997 Jul 4;40(14):2133-9.Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.

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