Drug Information

Drug General Information
Drug ID
D0U5FS
Former ID
DAP000980
Drug Name
Fluspirilene
Synonyms
Fluspirilen; Fluspirileno; Fluspirilenum; Imap; Redeptin; Spirodiflamine; R 6218; F-100; Fluspirileno [INN-Spanish]; Fluspirilenum [INN-Latin]; Imap (TN); Spiropiperidine analogue, 1; Fluspirilene (USAN/INN); Fluspirilene [USAN:INN:BAN]; McN-JR-6218; 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane; 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one; 8-[4,4-bis (p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4,5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one; 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Approved [543173], [550728]
Therapeutic Class
Antipsychotic Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C29H31F2N3O
InChI
InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
InChIKey
QOYHHIBFXOOADH-UHFFFAOYSA-N
CAS Number
CAS 1841-19-6
PubChem Compound ID
3396
PubChem Substance ID
5373984, 8152165, 11111163, 11112501, 11466934, 11468054, 11486687, 11532937, 15034182, 17396799, 17405081, 24277915, 26753577, 26753578, 29222531, 46508202, 47365394, 47365395, 47440449, 47515499, 47662490, 48185163, 48185164, 49699203, 50055682, 50106303, 50106304, 50106305, 50549166, 53777624, 56422781, 57298659, 57321776, 81093250, 85086165, 85209874, 85231040, 85788238, 90341058, 92125718, 92303784, 92308731, 92309759, 99300673, 103224650, 103914601, 104171151, 104303392, 121361281, 121363389
SuperDrug ATC ID
N05AG01
SuperDrug CAS ID
cas=001841196
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [535367]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 543173(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 85).
Ref 550728Drug information of Fluspirilene, 2008. eduDrugs.
Ref 535367Inhibition of glutamate release by fluspirilene in cerebrocortical nerve terminals (synaptosomes). Synapse. 2002 Apr;44(1):36-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.