Drug General Information
Drug ID
D0U4TN
Former ID
DNC007986
Drug Name
2-(2-hexylphenyl)isoindoline-1,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529375]
Structure
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2D MOL

3D MOL

Formula
C20H21NO2
Canonical SMILES
CCCCCCC1=CC=CC=C1N2C(=O)C3=CC=CC=C3C2=O
InChI
1S/C20H21NO2/c1-2-3-4-5-10-15-11-6-9-14-18(15)21-19(22)16-12-7-8-13-17(16)20(21)23/h6-9,11-14H,2-5,10H2,1H3
InChIKey
USXHUJLIZBGCGH-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529375]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.

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