Drug Information
Drug General Information | |||||
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Drug ID |
D0U3LK
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Former ID |
DIB014097
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Drug Name |
Metformin glycinate
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Synonyms |
DMMET-01; Metformin glycinate (diabetes); Type 2 diabetes therapy, Laboratorios Silanes; Metformin glycinate (diabetes), Laboratorios Silanes
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Drug Type |
Small molecular drug
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Indication | Type 2 diabetes [ICD9: 250; ICD10:E11] | Phase 2/3 | [1] | ||
Company |
Laboratorios Silanes SA De CV
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Structure |
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Download2D MOL |
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Formula |
C6H16N6O2
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Canonical SMILES |
C(=N)(NC(=N)N)N(C)C.C(=O)(CN)O
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Insulin receptor | Target Info | Inhibitor | [2] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
cGMP-PKG signaling pathway | |||||
HIF-1 signaling pathway | |||||
FoxO signaling pathway | |||||
PI3K-Akt signaling pathway | |||||
AMPK signaling pathway | |||||
Adherens junction | |||||
Insulin signaling pathway | |||||
Ovarian steroidogenesis | |||||
Type II diabetes mellitus | |||||
Non-alcoholic fatty liver disease (NAFLD) | |||||
Aldosterone-regulated sodium reabsorption | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
PANTHER Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
Insulin/IGF pathway-protein kinase B signaling cascade | |||||
PI3 kinase pathway | |||||
Pathway Interaction Database | Insulin Pathway | ||||
Signaling events mediated by PTP1B | |||||
Signaling events mediated by TCPTP | |||||
Insulin-mediated glucose transport | |||||
PathWhiz Pathway | Insulin Signalling | ||||
Leucine Stimulation on Insulin Signaling | |||||
Reactome | IRS activation | ||||
Signal attenuation | |||||
Insulin receptor signalling cascade | |||||
Insulin receptor recycling | |||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
Insulin Signaling | |||||
Nanoparticle triggered autophagic cell death | |||||
AGE/RAGE pathway | |||||
Signaling by Insulin receptor | |||||
Folate Metabolism | |||||
Type II diabetes mellitus | |||||
Vitamin B12 Metabolism | |||||
Selenium Micronutrient Network | |||||
AMPK Signaling | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT00940472) Study on DMMET-01 Versus Metformin on Improvement of Metabolic Control in Naive Type 2 Diabetes Patients. U.S. National Institutes of Health. | ||||
REF 2 | Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus. Diabetes Technol Ther. 2012 December; 14(12): 1140-1144. | ||||
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