Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U3LK
|
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| Former ID |
DIB014097
|
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| Drug Name |
Metformin glycinate
|
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| Synonyms |
DMMET-01; Metformin glycinate (diabetes); Type 2 diabetes therapy, Laboratorios Silanes; Metformin glycinate (diabetes), Laboratorios Silanes
|
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| Drug Type |
Small molecular drug
|
||||
| Indication | Type 2 diabetes [ICD9: 250; ICD10:E11] | Phase 2/3 | [1] | ||
| Company |
Laboratorios Silanes SA De CV
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C6H16N6O2
|
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| Canonical SMILES |
C(=N)(NC(=N)N)N(C)C.C(=O)(CN)O
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Insulin receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Adherens junction | |||||
| Insulin signaling pathway | |||||
| Ovarian steroidogenesis | |||||
| Type II diabetes mellitus | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Aldosterone-regulated sodium reabsorption | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
| Insulin/IGF pathway-protein kinase B signaling cascade | |||||
| PI3 kinase pathway | |||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by PTP1B | |||||
| Signaling events mediated by TCPTP | |||||
| Insulin-mediated glucose transport | |||||
| PathWhiz Pathway | Insulin Signalling | ||||
| Leucine Stimulation on Insulin Signaling | |||||
| Reactome | IRS activation | ||||
| Signal attenuation | |||||
| Insulin receptor signalling cascade | |||||
| Insulin receptor recycling | |||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| Insulin Signaling | |||||
| Nanoparticle triggered autophagic cell death | |||||
| AGE/RAGE pathway | |||||
| Signaling by Insulin receptor | |||||
| Folate Metabolism | |||||
| Type II diabetes mellitus | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00940472) Study on DMMET-01 Versus Metformin on Improvement of Metabolic Control in Naive Type 2 Diabetes Patients. U.S. National Institutes of Health. | ||||
| REF 2 | Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus. Diabetes Technol Ther. 2012 December; 14(12): 1140-1144. | ||||
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