Drug General Information
Drug ID	D0U2FN
Former ID	DIB009123
Drug Name	Romazarit
Synonyms	ORE-5007; Metabolic modulator (obesity/hyperlipidemia), Ore Pharmaceuticals
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Preclinical	[544776]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C15H16ClNO4
Canonical SMILES	C(C(=O)O)(OCc1c(nc(o1)c1ccc(cc1)Cl)C)(C)C
CAS Number	CAS 109543-76-2
PubChem Compound ID	71321
Target and Pathway
Target(s)	Peroxisome proliferator activated receptor alpha	Target Info	Modulator	[544293]
KEGG Pathway	PPAR signaling pathway
	cAMP signaling pathway
	Adipocytokine signaling pathway
	Glucagon signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
Pathway Interaction Database	RXR and RAR heterodimerization with other nuclear receptor
Reactome	RORA activates gene expression
	BMAL1:CLOCK,NPAS2 activates circadian gene expression
	PPARA activates gene expression
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Transcriptional activation of mitochondrial biogenesis
	Activation of gene expression by SREBF (SREBP)
	Transcriptional regulation of white adipocyte differentiation
	Nuclear Receptor transcription pathway
	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Circadian Clock
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	PPAR Alpha Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Transcriptional Regulation of White Adipocyte Differentiation
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Activation of Gene Expression by SREBP (SREBF)
	Adipogenesis
	SREBF and miR33 in cholesterol and lipid homeostasis
	Circadian Clock
	Nuclear Receptors
References
Ref 544776	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000969)
Ref 544293	Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review. Ther Adv Musculoskelet Dis. 2013 February; 5(1): 33-44.

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