Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U1UZ
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| Former ID |
DNC006690
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| Drug Name |
C(his-D-phe-arg-trp-Abu)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C36H45N11O5
|
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| Canonical SMILES |
C1CCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC1)CC2=CNC3=<br />CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
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| InChI |
1S/C38H49N11O5/c39-38(40)43-17-9-14-29-35(52)49-31(19-25-21-44-28-13-7-6-12-27(25)28)34(51)42-16-8-2-5-15-33(50)46-32(20-26-22-41-23-45-26)37(54)48-30(36(53)47-29)18-24-10-3-1-4-11-24/h1,3-4,6-7,10-13,21-23,29-32,44H,2,5,8-9,14-20H2,(H,41,45)(H,42,51)(H,46,50)(H,47,53)(H,48,54)(H,49,52)(H4,39,40,43)/t29-,30+,31-,32+/m0/s1
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| InChIKey |
NKDXCOMNRCSRHU-MLMSKLGMSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Melanocortin-4 receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Pathway Interaction Database | Syndecan-3-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. Epub 2006 May 5.Design of cyclic peptides with agonist activity at melanocortin receptor-4. | ||||
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