Drug General Information
Drug ID	D0U1NA
Former ID	DIB007892
Drug Name	Fadolmidine
Synonyms	Fadolmidine hydrochloride; MPV-2426
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[547121]
Company	Orion Corp
Structure		Download 2D MOL 3D MOL
Formula	C13H14N2O
Canonical SMILES	c12C(Cc3[nH]cnc3)CCc1ccc(c2)O.Cl
PubChem Compound ID	6433098
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Agonist	[527103]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547121	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013220)
Ref 527103	Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10(2):117-26.

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