Drug General Information
Drug ID	D0U1HN
Former ID	DIB014509
Drug Name	AM-211
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 1	[548899]
Company	Amira Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C27H27F3N2O4
Canonical SMILES	CCN(CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=CC(=C2)CC(=O)O)OC)C(<br />=O)NCC3=CC=CC=C3
InChIKey	OPXIRFWNLBDKQB-UHFFFAOYSA-N
PubChem Compound ID	44158492
PubChem Substance ID	85158582, 89937034, 163321861, 163346664, 163643199, 198985751, 224476444, 226505790, 246710691
Target and Pathway
Target(s)	Putative G-protein coupled receptor 44	Target Info	Antagonist	[531433]
Reactome	Prostanoid ligand receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548899	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030063)
Ref 531433	Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301.

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