Drug General Information
Drug ID
D0TV6I
Former ID
DCL000972
Drug Name
Safinamide
Synonyms
Fce 26743; M6252; Fce-26743; N2-{4-[(3-fluorobenzyl)oxy]benzyl}-L-alaninamide; (2R)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide; (2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide; (S)-2-(((4-((3-Fluorophenyl)methoxy)phenyl)methyl)amino)propanamide; 2-(4-(3-Fluorobenzyloxy)benzylamino)propionamide
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [889446]
Idiopathic parkinson's disease [ICD9: 332; ICD10:F02.3, G20] Phase 3 [536923], [543044]
Company
Us Worldmeds
Structure
Download
2D MOL

3D MOL

Formula
C17H19FN2O2
InChI
InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
InChIKey
NEMGRZFTLSKBAP-LBPRGKRZSA-N
CAS Number
CAS 133865-89-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [536266], [536498]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compounds
References
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
Ref 543044(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8291).
Ref 889446Drugs@FDA (Edaravone)
Ref 536266Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17.
Ref 536498Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.

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