Drug General Information
Drug ID	D0TN2R
Former ID	DNC012106
Drug Name	3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525507]
Structure		Download 2D MOL 3D MOL
Formula	C11H15NO
Canonical SMILES	COCC1CC2=CC=CC=C2CN1
InChI	1S/C11H15NO/c1-13-8-11-6-9-4-2-3-5-10(9)7-12-11/h2-5,11-12H,6-8H2,1H3
InChIKey	IDSUOIGUQHWCCU-UHFFFAOYSA-N
PubChem Compound ID	10797392
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[525507]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[525507]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[525507]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 525507	J Med Chem. 1999 Jun 3;42(11):1982-90.3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.
Ref 525507	J Med Chem. 1999 Jun 3;42(11):1982-90.3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.

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