Drug Information

Drug General Information
Drug ID
D0T9NX
Former ID
DNC008517
Drug Name
1-(3-methylpyridin-2-yl)-4-tosylpiperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529500]
Structure
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2D MOL

3D MOL
Formula
C17H21N3O2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=C(C=CC=N3)C
InChI
1S/C17H21N3O2S/c1-14-5-7-16(8-6-14)23(21,22)20-12-10-19(11-13-20)17-15(2)4-3-9-18-17/h3-9H,10-13H2,1-2H3
InChIKey
VJVLLYXNCKJIIY-UHFFFAOYSA-N
PubChem Compound ID
44237027
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [529500]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 529500Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. Epub 2008 May 10.Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Ref 529500Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. Epub 2008 May 10.Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

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