Drug General Information
Drug ID	D0T9BB
Former ID	DNC011331
Drug Name	7-methoxy-8-propionyl-2H-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531259]
Structure		Download 2D MOL 3D MOL
Formula	C13H12O4
Canonical SMILES	CCC(=O)C1=C(C=CC2=C1OC(=O)C=C2)OC
InChI	1S/C13H12O4/c1-3-9(14)12-10(16-2)6-4-8-5-7-11(15)17-13(8)12/h4-7H,3H2,1-2H3
InChIKey	XQJPTVQKFUWDCL-UHFFFAOYSA-N
PubChem Compound ID	52950111
Target and Pathway
Target(s)	Carbonic anhydrase IX	Target Info	Inhibitor	[531259]
KEGG Pathway	Nitrogen metabolism
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxide
WikiPathways	Vitamin D Receptor Pathway
	Reversible Hydration of Carbon Dioxide
	Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 531259	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Ref 531259	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.

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