Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T8MA
|
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| Former ID |
DIB005567
|
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| Drug Name |
ATN-224
|
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| Synonyms |
Angiogenesis inhibitor, Attenuon; Superoxide dismutase 1 inhibitor, Attenuon
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 2 | [1] | ||
| Company |
University of Michigan
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C10H30MoN2O2S4
|
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| Canonical SMILES |
S=[Mo-2](=S)(=S)=S.C[N+](C)(CCO)C.C[N+](C)(CCO)C
|
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| CAS Number |
CAS 649749-10-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Superoxide dismutase [Cu-Zn] | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Reactive oxygen species degradation | ||||
| KEGG Pathway | Peroxisome | ||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Prion diseases | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| Pathway Interaction Database | Validated nuclear estrogen receptor alpha network | ||||
| FOXA1 transcription factor network | |||||
| PathWhiz Pathway | Degradation of Superoxides | ||||
| Reactome | Platelet degranulation | ||||
| Detoxification of Reactive Oxygen Species | |||||
| WikiPathways | Oxidative Stress | ||||
| Copper homeostasis | |||||
| Detoxification of Reactive Oxygen Species | |||||
| Nifedipine Activity | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Dopamine metabolism | |||||
| AGE/RAGE pathway | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00405574) Study of ATN-224 in Patients With Prostate Cancer. U.S. National Institutes of Health. | ||||
| REF 2 | Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. | ||||
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