TTD | Drug: D0T8CE

Drug General Information
Drug ID	D0T8CE
Former ID	DNCL002631
Drug Name	AMG888/U3-1287
Indication	Non-small cell lung cancer [ICD10:C33-C34]		Phase 1/2	[523187]
Company	Amgen
Target and Pathway
Target(s)	Receptor protein-tyrosine kinase erbB-3	Target Info	Modulator	[543486]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	Endocytosis
	Proteoglycans in cancer
	MicroRNAs in cancer
NetPath Pathway	TNFalpha Signaling Pathway
PANTHER Pathway	Cadherin signaling pathway
PANTHER Pathway	EGF receptor signaling pathway
Pathway Interaction Database	ErbB2/ErbB3 signaling events
	ErbB receptor signaling network
	a6b1 and a6b4 Integrin signaling
WikiPathways	ErbB Signaling Pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Signaling Pathways in Glioblastoma
	miR-targeted genes in muscle cell - TarBase
	Heart Development
References
Ref 523187	ClinicalTrials.gov (NCT01211483) Study of Erlotinib With or Without Investigational Drug (U3-1287) in Subjects With Advanced Non-small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 543486	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798).

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Drug Information