TTD | Drug: D0T7CM

Drug General Information
Drug ID	D0T7CM
Former ID	DPR000117
Drug Name	UCL-2000 and butabindide
Indication	Obesity [ICD9: 278; ICD10:E66]		Discontinued in Phase 1	[551995]
Company	University College London
CAS Number	CAS 185213-03-0
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Agonist	[536122]
Target(s)	Tripeptidyl-peptidase II	Target Info	Inhibitor	[536122]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling eventsR-HSA-983168:Antigen processing: Ubiquitination & Proteasome degradation
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551995	Clinical pipeline report, company report or official report of University College London.
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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Drug Information