Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T6MU
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| Former ID |
DIB012313
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| Drug Name |
FR-113680
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C35H39N5O6
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| Canonical SMILES |
n1(cc(c2c1cccc2)C[C@H](C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)C<br />c1ccccc1)NC(=O)[C@@H](NC(=O)C)[C@H](O)C)C=O
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| CAS Number |
CAS 126088-92-4
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001352) | ||||
| REF 2 | FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6. | ||||
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