TTD | Drug: D0T6MU

Drug General Information
Drug ID	D0T6MU
Former ID	DIB012313
Drug Name	FR-113680
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[544862]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C35H39N5O6
Canonical SMILES	n1(cc(c2c1cccc2)C[C@H](C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)C<br />c1ccccc1)NC(=O)[C@@H](NC(=O)C)[C@H](O)C)C=O
CAS Number	CAS 126088-92-4
PubChem Compound ID	130848
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Inhibitor	[526802]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544862	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001352)
Ref 526802	FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6.

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Drug Information