Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T6DU
|
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| Former ID |
DIB020589
|
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| Drug Name |
OAG
|
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| Synonyms |
1-oleoyl-2-acetyl-sn-glycerol
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539564] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H42O5
|
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| InChI |
InChI=1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10+
|
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| InChIKey |
PWTCCMJTPHCGMS-ZHACJKMWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Short transient receptor potential channel 3 | Target Info | Activator | [534828] | |
| Short transient receptor potential channel 6 | Target Info | Activator | [534828] | ||
| TRPC2 | Target Info | Activator | [526896] | ||
| TRPC7 | Target Info | Activator | [525586] | ||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| References | |||||
| Ref 525586 | Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70. | ||||
| Ref 526896 | A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. | ||||
| Ref 534828 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. | ||||
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