Drug Information

Drug General Information
Drug ID
D0T5LQ
Former ID
DIB000872
Drug Name
123-Iodine-labeled MFE-23
Synonyms
CEA antibody program (cancer/imaging); MFE-23-albumin fusion protein; CEA antibody program (cancer/imaging), Cancer Research Technology/UCL/Novozymes Delta; Albumin-linked anti-CEA single chain antibody fragment (cancer), UCL/CRT/Novozymes; Anti-CEA scFv-albumin fusion (cancer), UCL/CRT/Novozymes; 123-Iodine-labeledMFE-23; 125-I-labeled MFE-23-his; 125-Iodine-labeled MFE-23; 99mTc-labeled MFE-23
Drug Type
Antibody
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [530224]
Company
University College London
Target and Pathway
Target(s) Carcinoembryonic antigen-related cell adhesion molecule 5 Target Info [543999]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
References
Ref 530224A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas. Clin Cancer Res. 2009 Jul 1;15(13):4484-92.
Ref 543999Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts.. Biochem J. 2000 March 1; 346(Pt 2): 519-528.

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