Drug Information

Drug General Information
Drug ID
D0T5GT
Former ID
DNC000395
Drug Name
CE-1037
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [545583]
Structure
Download
2D MOL

3D MOL
Formula
C36H42O12S2
Canonical SMILES
CC(C)(CS(=O)(=O)C1=CC=C(C=C1)OC(=O)C(C)(C)C2=CC=C(C=C2)<br />C(C)(C)C(=O)OC3=CC=C(C=C3)S(=O)(=O)CC(C)(C)C(=O)O)C(=O)<br />O
InChI
1S/C36H42O12S2/c1-33(2,29(37)38)21-49(43,44)27-17-13-25(14-18-27)47-31(41)35(5,6)23-9-11-24(12-10-23)36(7,8)32(42)48-26-15-19-28(20-16-26)50(45,46)22-34(3,4)30(39)40/h9-20H,21-22H2,1-8H3,(H,37,38)(H,39,40)
InChIKey
HVXFLNJFYRWDQU-UHFFFAOYSA-N
CAS Number
CAS 150493-09-7
PubChem Compound ID
9875205
PubChem Substance ID
14840143, 24164504, 45622179, 77066672, 103245582, 103954425, 128120810, 135262501, 234428294
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 545583Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003784)
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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