Drug Information

Drug General Information
Drug ID
D0T4YQ
Former ID
DIB021173
Drug Name
VU0092273
Synonyms
VU 0092273
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541560]
Structure
Download
2D MOL
Formula
C20H19NO2
InChI
InChI=1S/C20H19NO2/c22-19-12-14-21(15-13-19)20(23)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16/h1-5,8-11,19,22H,12-15H2
InChIKey
FPDBSDNGFNDSSK-UHFFFAOYSA-N
PubChem Compound ID
16000100
PubChem Substance ID
24349987, 26200683, 28679831, 37124064, 47393309, 56449914, 57875747, 71823562, 89830526, 124962682, 125003262, 125088059, 125311631, 131703603, 137376874, 143472298, 170046743, 178103037, 196362830, 229636594, 247780168
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator (allosteric modulator) [531671]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 541560(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6421).
Ref 531671Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol.2012 Feb;81(2):120-33.

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